Anticarcinogenic activity of methanol extract of Melastoma malabathricum leaves is attributed to the presence of phenolics compounds and the activation of endogenous antioxidant system

IF 0.7 4区医学 Q4 INTEGRATIVE & COMPLEMENTARY MEDICINE Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas Pub Date : 2022-01-30 DOI:10.37360/blacpma.22.21.1.04

Zainul Amiruddin Zakaria, Noorsyaza Eddrina Kamsani, Roro Azizah, Lilis Sulistyorini

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Abstract

Melastoma malabathricum (M. malabathricum) extracts have been reported to exert various pharmacological activities including antioxidants, anti-inflammatory and antiproliferative activities. The objective of the present study was to determine the anticarcinogenic activity of its methanol extract (MEMM) against the azoxymethane (AOM)-induced early colon carcinogenesis in rats. Rats were randomly assigned to five groups (n=6) namely normal control, negative control, and treatment (50, 250 or 500 mg/kg of MEMM) groups. Colon tissues were harvested for histopathological analysis and endogenous antioxidant system determination. MEMM was also subjected to HPLC analysis. Findings showed that MEMM significantly (p<0.05) reversed the AOM-induced carcinogenicity by: i) reducing the formation of aberrant crypt foci (ACF) in colon tissues, and; ii) enhancing the endogenous antioxidant activity (catalase, superoxide dismutase and glutathione peroxidase). Moreover, various phenolics has been identified in MEMM. In conclusion, MEMM exerts the in vivo anticarcinogenic activity via the activation of endogenous antioxidant system and synergistic action of phenolics.

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黑草叶甲醇提取物的抗癌活性与酚类化合物的存在和内源性抗氧化系统的激活有关

malabathricum (M. malabathricum)提取物具有多种药理活性，包括抗氧化、抗炎和抗增殖活性。本研究的目的是确定其甲醇提取物(MEMM)对偶氮氧甲烷(AOM)诱导的大鼠早期结肠癌的抗癌活性。将大鼠随机分为正常对照组、阴性对照组和治疗组(50、250、500 mg/kg MEMM) 5组(n=6)。收集结肠组织进行组织病理学分析和内源性抗氧化系统测定。MEMM也进行了HPLC分析。结果表明，MEMM显著(p<0.05)逆转aom诱导的致癌性，其机制是:1)减少结肠组织中异常隐窝灶(ACF)的形成;Ii)增强内源性抗氧化活性(过氧化氢酶、超氧化物歧化酶和谷胱甘肽过氧化物酶)。此外，MEMM中还发现了多种酚类物质。综上所述，MEMM通过激活内源性抗氧化系统和酚类物质的协同作用发挥体内抗癌活性。

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来源期刊

Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas PHARMACOLOGY & PHARMACY-

CiteScore

1.30

自引率

14.30%

发文量

审稿时长

6-12 weeks

期刊介绍： The Boletín Latinoamericano y del Caribe de Plantas Medicinales y Aromáticas (BLACPMA), [Latin American and Caribbean Bulletin of Medicinal and Aromatic Plants]; currently edited by the publishing house MS-Editions, is a bi-monthly international publication that publishes original peerreviewed research in the field of medicinal and aromatic plants, with nearly 20 years of experience. BLACPMA is a scientific journal that publishes two types of articles: Reviews (only in English) and Original Articles (Spanish or English), its main lines of action being agronomy, anthropology and ethnobotany, industrial applications, botany, quality and standardization, ecology and biodiversity, pharmacology, phytochemistry, pharmacognosy, regulatory and legislative aspects. While all areas of medicinal plants are welcome and the experimental approaches used can be broad and interdisciplinary; other areas of research that are not mentioned depend on the Editorial Committee for their acceptance.