Synthesis, Molecular Docking Studies and Antibacterial Evaluation of Baylis-Hillman Adducts of Coumarin and Pyran Derivatives Using Ionic Liquid under Microwave Irradiation

A. Kumar, S. Kanakaraju, B. Prasanna, G. Chandramouli
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引用次数: 11

Abstract

The Baylis-Hillman adducts 3(a-e) and 6(a-g) were prepared by the reaction of appropriate aldehydes with alkenes in presence of catalytic amount of urotropine with ionic liquids under microwave irradiation. Structures of the newly synthesized compounds were characterized by spectral studies. The antibacterial studies of Baylis-Hilmann compounds for analysis of the structural requirements for antibacterial activity using VLife MDS 3.5 has been carried out.
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微波辐射下离子液体香豆素和吡喃衍生物Baylis-Hillman加合物的合成、分子对接研究及抗菌评价
在离子液体的催化作用下,在微波照射下,适当的醛与烯烃反应制备了Baylis-Hillman加合物3(a-e)和6(a-g)。新合成化合物的结构通过光谱研究进行了表征。利用VLife MDS 3.5对Baylis-Hilmann化合物进行抑菌研究,分析其抑菌活性的结构要求。
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