ABREVIATURAS

Abstract

Athayde DAM. Metabolic alterations and growth disorders in children born with very low birth weight and preterm infants small for gestational age at 36 months of INTRODUCTION Medical advances have allowed the survival of newborns (NB) with increasingly lower gestational age (GA) and birth weight. However, these children may have difficulty in gaining weight and height, as well as early changes in metabolic parameters. Objectives: To evaluate the clinical and metabolic characteristics of very low birth weight preterm newborns (RNPTMB) at the first thirty-six months of life, comparing the Appropriate for Gestational Age (AGA) and Small for Gestational Age (SGA) groups. METHODS This is a retrospective cohort study, with data collection through a review of the medical records of the RNPTMBP, hospitalized in the neonatal intensive care center, from 2008 to 2014, who were discharged and followed up at the follow-up outpatient clinic to NB at risk at the Instituto da Criança of HCFMUSP. Anthropometric data at birth, at hospital discharge and at 36 months of gestational age corrected for prematurity were analyzed. Z-scores for weight, length/height at 36 months were calculated using the WHO 2006-2007 reference. Laboratory tests were measured (total cholesterol and fractions, blood glucose) with approximately 36 months (30-52 months) of PCI. RESULTS The sample comprised 185 patients, 94 (50.8%) SGA and 91 (49.2%) AGA. Of the 185 patients, 99 (53.5%) children were female. Mean gestational age was 30.6 (±2.6) weeks, being significantly lower in the AGA group (p<0.0001). Patients were hospitalized for an average of 63.1±30.2 days. At birth, the mean weight was 1.096 (±0.252) and the length was 35.9 cm (±2.9). Z-scores for weight and length were lower in the SGA group. (p<0.0001). During hospitalization, there was a weight loss in both groups, z-score change of (+- 0.9) AIG group of - 1.39 (+-0.9) for the PIG group. Both groups (AIG and SGA) this significant reduction in the weight and length Z-score between birth and discharge, followed by an increase between discharge and the 36-month follow-up. Among the SGA, 70.2% had catch-up for weight and 71.2% (n=67) catch-up for length, remaining above the z-score -2 at 36 months of gestational age corrected for prematurity. The values of the lipid profile tests (total cholesterol and fractions), as well as the blood glucose concentrations, similar between the groups, at 36 months of PCI, with no statistical differences. Newborns who developed EUGR (extrauterine growth restriction defined

查看原文

分享

微信好友 朋友圈 QQ好友 复制链接

本刊更多论文

Athayde大坝。出生时出生体重极低的儿童和出生36个月时小于胎龄的早产儿的代谢改变和生长障碍医学进步使胎龄和出生体重越来越低的新生儿(NB)得以存活。然而，这些孩子可能难以增加体重和身高，以及代谢参数的早期变化。目的:评价极低出生体重早产儿(RNPTMB)出生后前36个月的临床和代谢特征，比较适胎龄组(AGA)和小胎龄组(SGA)。方法:回顾性队列研究，通过回顾2008年至2014年在新生儿重症监护中心住院的RNPTMBP患者的医疗记录，并在HCFMUSP crian研究所随访门诊随访至高危新生儿。对出生时、出院时和胎龄36个月时的人体测量数据进行分析。36个月时体重、长度/身高的z分数使用世卫组织2006-2007参考资料计算。在PCI治疗约36个月(30-52个月)时测量实验室测试(总胆固醇和分数、血糖)。结果185例患者中，SGA 94例(50.8%)，AGA 91例(49.2%)。185例患儿中，99例(53.5%)为女童。平均胎龄为30.6(±2.6)周，AGA组明显低于对照组(p<0.0001)。患者平均住院时间63.1±30.2 d。出生时平均体重1.096(±0.252)，平均体长35.9 cm(±2.9)。体重和长度的z分数在SGA组较低。(p < 0.0001)。住院期间，两组患者体重均有所下降，AIG组的z-score变化为(+-0.9)，PIG组的z-score变化为- 1.39(+-0.9)。两组(AIG和SGA)在出生和出院之间的体重和长度z评分显著降低，随后在出院和36个月的随访期间增加。在SGA中，70.2%的人体重赶上，71.2% (n=67)的人长度赶上，在36个月胎龄校正早产后保持在-2以上。在PCI治疗36个月时，两组之间的血脂测试值(总胆固醇和分数)以及血糖浓度相似，无统计学差异。发生EUGR(出院时定义为子宫外生长受限

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文 去求助

相关文献