Matthew A. Nitka, Katarina E. Zerbee, Julianne M. Dee, Matthew A. Cranswick, E. Zovinka, John R. De Backere
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引用次数: 0
Abstract
ABSTRACT While porphyrin-related syntheses have become classic experiments in the undergraduate curriculum, traditional syntheses of the free-base meso-tetraphenylporphyrin (H2TPP) and its metallated derivatives can be energy-intensive, use hazardous solvents, and generate appreciable amounts of waste. In an attempt to make the synthesis of H2TPP and its metallated derivatives (MTPP where M = metal) better aligned with the principles of green chemistry, we optimized a microwave-assisted, microscale synthesis of H2TPP and alternative routes toward the metallation of H2TPP including solvent-substituted reflux and mechanochemical syntheses for the undergraduate teaching laboratory. The greenness of these syntheses were evaluated using various green metrics and qualitative comparison to previously reported syntheses. GRAPHICAL ABSTRACT
期刊介绍：
Green Chemistry Letters and Reviews is an Open Access, peer-reviewed journal focused on rapid publication of innovative new syntheses and procedures that reduce or eliminate the use and generation of hazardous materials. Reviews of state-of-the-art green chemistry technologies are also included within the journal''s scope.
Green Chemistry Letters and Reviews is divided into three overlapping topic areas: research, education, and industrial implementation. The journal publishes both letters, which concisely communicate the most time-sensitive results, and reviews, which aid researchers in understanding the state of science on important green chemistry topics. Submissions are encouraged which apply the 12 principles of green chemistry to:
-Green Chemistry Education-
Synthetic Reaction Pathways-
Research and Process Analytical Techniques-
Separation and Purification Technologies-
Renewable Feedstocks-
Degradable Products
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