{"title":"X Function","authors":"","doi":"10.1126/scisignal.1132001tw464","DOIUrl":null,"url":null,"abstract":"Hepatitis B virus (HBV) infects 300 million people worldwide and causes liver disease and cancer. The X-protein of HBV is essential for viral infection and has been implicated in carcinogenesis, but its exact role has been enigmatic. It is known to infiltrate cell signaling pathways and to activate modest transcription from various promoters, as well as strongly activate viral replication in certain cell lines. The X-protein activates Src without interacting directly with Src. Bouchard et al. (see the Perspective by Ganem) have now discovered that this activation is mediated the activation of another kinase called Pyk. The activation of Pyk is caused by a release of calcium from intracellular stores (most likely the mitochondrion) triggered by X-protein. M. J. Bouchard, L.-H. Wang, R. J. Schneider, Calcium signaling by HBx protein in hepatitis B virus DNA replication. Science 294, 2376-2378 (2001). [Abstract] [Full Text] D. Ganem, The X files--one step closer to closure. Science 294, 2299-2300 (2001). [Full Text]","PeriodicalId":21619,"journal":{"name":"Science's STKE","volume":"11 1","pages":"tw464 - tw464"},"PeriodicalIF":0.0000,"publicationDate":"2001-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Science's STKE","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1126/scisignal.1132001tw464","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 1
Abstract
Hepatitis B virus (HBV) infects 300 million people worldwide and causes liver disease and cancer. The X-protein of HBV is essential for viral infection and has been implicated in carcinogenesis, but its exact role has been enigmatic. It is known to infiltrate cell signaling pathways and to activate modest transcription from various promoters, as well as strongly activate viral replication in certain cell lines. The X-protein activates Src without interacting directly with Src. Bouchard et al. (see the Perspective by Ganem) have now discovered that this activation is mediated the activation of another kinase called Pyk. The activation of Pyk is caused by a release of calcium from intracellular stores (most likely the mitochondrion) triggered by X-protein. M. J. Bouchard, L.-H. Wang, R. J. Schneider, Calcium signaling by HBx protein in hepatitis B virus DNA replication. Science 294, 2376-2378 (2001). [Abstract] [Full Text] D. Ganem, The X files--one step closer to closure. Science 294, 2299-2300 (2001). [Full Text]
乙型肝炎病毒(HBV)感染了全世界3亿人，并导致肝脏疾病和癌症。HBV的x蛋白是病毒感染所必需的，并与癌变有关，但其确切作用仍是谜。众所周知，它可以渗透细胞信号通路，激活各种启动子的适度转录，并在某些细胞系中强烈激活病毒复制。x蛋白激活Src而不直接与Src相互作用。Bouchard等人(参见Ganem的观点)现在发现，这种激活是由另一种名为Pyk的激酶的激活介导的。Pyk的激活是由x蛋白触发的细胞内储存(最有可能是线粒体)钙的释放引起的。M. J.布沙尔，l . h .;乙肝病毒DNA复制中HBx蛋白钙信号转导的研究。科学294,2376-2378(2001)。【摘要】【全文】D. Ganem, The X files——离结案又近了一步。科学29,2299-2300(2001)。(全文)
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