HYDROXYAPATITE NANOPARTICLES ALLEVIATE THE ADVERSE HEALTH PROBLEMES OF BISPHENOL A

Abstract

Bisphenol A (BPA) is one of the most detrimental pollutants in environment. Inside the body, it is metabolized by the liver and hence triggers liver injury. Hydroxyapatite nanoparticles (HANPs) are selected in the current study as a safe way to adsorb the BPA and hence eliminate its toxic impacts in vivo . HANPs formula was prepared by sol-gel techniques; characterization was confirmed by XRD, FTIR, morphology and thermal stability. In vivo study was conducted on Forty male rats which were equally divided into 4 groups. The negative control received 10%DMSO solution, HANPs group were ingested with 1g/ kg b.wt./day of HANPs, BPA group received 100 mg BPA/ kg b.w.t/ day, and the BPA+HANPs group were treated with 1 g HANPs/100mg BPA/ kg b.w.t/ day. The doses were given daily for six consecutive weeks orally. Blood samples were collected; serum was separated and used for determination of selected liver enzymes and lipid profile parameters. ALT