{"title":"Determination of Flucytosine in Human Serum using Liquid Chromatography-Tandem Mass Spectrometry","authors":"J. Alffenaar, K. V. Hateren, D. Touw","doi":"10.17145/jab.18.020","DOIUrl":null,"url":null,"abstract":"OBJECTIVES: Flucytosine is an important drug for the combination treatment of cryptococcal meningitis in patients suffering from an infection with human immunodeficiency virus. As new synergistic regimens are being explored in clinical trials a full oral regimen may be near. For such a study evaluation of drug exposure is of critical importance as bioavailability could be compromised and elimination highly depends on renal function. No simple LC-MS/MS method for therapeutic drug monitoring of flucytosine has been published.","PeriodicalId":15014,"journal":{"name":"Journal of Applied Bioanalysis","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2018-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Applied Bioanalysis","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.17145/jab.18.020","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 2
Abstract
OBJECTIVES: Flucytosine is an important drug for the combination treatment of cryptococcal meningitis in patients suffering from an infection with human immunodeficiency virus. As new synergistic regimens are being explored in clinical trials a full oral regimen may be near. For such a study evaluation of drug exposure is of critical importance as bioavailability could be compromised and elimination highly depends on renal function. No simple LC-MS/MS method for therapeutic drug monitoring of flucytosine has been published.
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