Antipsychotics With Different Chemical Structures Cause Different Degrees of Functional Impairments in the Primary Visual Cortex in a Murine Model: A Pilot Study.
Si Gao, Xiaoyan Ma, Feng Ji, Ce Chen, Deguo Jiang, Yong Xu, Xueqin Song, Wenqiang Wang, Xiaodong Lin, Hongjun Tian, Chuanjun Zhuo, Xinwu Ye, Haiping Yu
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Abstract
Background: Antipsychotic medications can impair vision in patients with schizophrenia. However, little is known regarding the pharmacodynamics of antipsychotics in the primary visual cortex. We aimed to study the pharmacodynamics of antipsychotics in the visual cortex in a murine model.
Methods: We used an adapted 2-photon imaging technique to observe changes in calcium dynamics induced by 4 antipsychotics (olanzapine, risperidone, aripiprazole, and amisulpride) in the primary visual cortex of healthy and schizophrenic C57BL/6 mice. Visual function was further assessed by using a novel object recognition test.
Results: All 4 antipsychotics decreased calcium activity in the primary visual cortex and reduced visual recognition test scores in healthy and schizophrenic mice. The most potent drug was olanzapine, followed by risperidone, aripiprazole, and amisulpride. All drugs showed significant differences between groups.
Conclusion: Our pilot study demonstrated that antipsychotics impair visual cortical function. This finding underscores the importance of monitoring for visual adverse events in patients receiving antipsychotic medications to treat schizophrenia.
期刊介绍：
The journal publishes research articles, letters/communications and reviews written by faculty members, researchers and postgraduates in universities, colleges and research institutes all over China and overseas. It reports the latest and most creative results of important fundamental research in all aspects of chemistry and of developments with significant consequences across subdisciplines.
Main research areas include (but are not limited to):
Organic chemistry (synthesis, characterization, and application);
Inorganic chemistry (bio-inorganic chemistry, inorganic material chemistry);
Analytical chemistry (especially chemometrics and the application of instrumental analysis and spectroscopy);
Physical chemistry (mechanisms, catalysis, thermodynamics and dynamics);
Polymer chemistry and polymer physics (mechanisms, material, catalysis, thermodynamics and dynamics);
Quantum chemistry (quantum mechanical theory, quantum partition function, quantum statistical mechanics);
Biochemistry;
Biochemical engineering;
Medicinal chemistry;
Nanoscience (nanochemistry, nanomaterials).
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