W. Busse, Millie Wang, J. Gibson, Mattis Gottlow, M. Braddock, G. Colice
{"title":"TROPOS: designing a clinical trial to evaluate the oral corticosteroid-sparing effect of a biologic in severe asthma","authors":"W. Busse, Millie Wang, J. Gibson, Mattis Gottlow, M. Braddock, G. Colice","doi":"10.4155/CLI.15.37","DOIUrl":null,"url":null,"abstract":"In a Phase IIb study, administration of tralokinumab, an anti-IL-13, fully human monoclonal antibody, to patients with severe uncontrolled asthma treated with high-dose inhaled corticosteroid (ICS) and long-acting β2-agonists (LABA) significantly improved lung function. Since many patients with severe asthma using ICS-LABA only achieve symptom control with add-on oral corticosteroids (OCS), an unmet need for OCS-sparing treatment strategies exists. This Phase III, randomized, double-blind, parallel-group, placebo-controlled TROPOS (NCT02281357) study will evaluate the OCS-sparing potential of tralokinumab in patients with severe asthma requiring continuous ICS-LABA and chronic maintenance OCS. After an initial screening/assessment period, patients will be randomized to tralokinumab or placebo for 40 weeks (12-week induction, 20-week OCS reduction and 8-week maintenance phases); patients will be followed-up for 14 weeks.","PeriodicalId":10369,"journal":{"name":"Clinical investigation","volume":"125 1","pages":"723-730"},"PeriodicalIF":0.0000,"publicationDate":"2015-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"10","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical investigation","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4155/CLI.15.37","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 10
Abstract
In a Phase IIb study, administration of tralokinumab, an anti-IL-13, fully human monoclonal antibody, to patients with severe uncontrolled asthma treated with high-dose inhaled corticosteroid (ICS) and long-acting β2-agonists (LABA) significantly improved lung function. Since many patients with severe asthma using ICS-LABA only achieve symptom control with add-on oral corticosteroids (OCS), an unmet need for OCS-sparing treatment strategies exists. This Phase III, randomized, double-blind, parallel-group, placebo-controlled TROPOS (NCT02281357) study will evaluate the OCS-sparing potential of tralokinumab in patients with severe asthma requiring continuous ICS-LABA and chronic maintenance OCS. After an initial screening/assessment period, patients will be randomized to tralokinumab or placebo for 40 weeks (12-week induction, 20-week OCS reduction and 8-week maintenance phases); patients will be followed-up for 14 weeks.