CHAPTER 1. New Polymers From SuFEx Click Chemistry: Syntheses and Perspectives

Abstract

Sulfur(vi) Fluoride Exchange (SuFEx) click chemistry was reported by Sharpless et al. in 2014. The applications of SuFEx click chemistry have been demonstrated in various disciplines since then, including the development of synthetic methods and the preparation of polymers. Fluorosulfates have also been found to be unique warheads for covalent capture of protein side chains in a highly selective, context-dependent manner. A review of the story of discovering SuFEx will be included in this chapter. We will also focus on the details demonstrating the whole process to synthesize new polysulfonate and polysulfate polymers, especially the evolution of the catalysts involved. Aside from leading to the discovery of new polymers, SuFEx click chemistry as a powerful tool in polymer modification will also be discussed herein.