Systemic sclerosis: new insights in autoimmunity.

S. Kaal, F. V. D. van den Hoogen, E. D. De Jong, H. Viëtor
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引用次数: 12

Abstract

The strong female predilection of systemic sclerosis, especially in women after their childbearing years, and the clinical and histopathological similarities with chronic graft-versus-host disease make systemic sclerosis an interesting subject of debate. Recent studies concerning the pathogenesis of this disease demonstrated the persistence of fetal cells in the maternal circulation in a majority of female patients. How or whether microchimerism is involved in the pathogenesis of systemic sclerosis remains to be elucidated. The present paper reviews the recent findings on the subject.
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系统性硬化症:自身免疫的新见解。
女性对系统性硬化症的强烈偏好,尤其是育龄后的女性,以及与慢性移植物抗宿主病的临床和组织病理学相似性,使系统性硬化症成为一个有趣的争论话题。最近关于该病发病机制的研究表明,在大多数女性患者中,胎儿细胞在母体循环中持续存在。微嵌合如何或是否参与系统性硬化症的发病机制仍有待阐明。本文综述了这方面的最新研究成果。
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