{"title":"Application of a Mouse Ex Vivo Spermatogenesis Model to Elucidate the Mechanism of Radio-Therapy-Related Male Infertility","authors":"K. Kaminaga, A. Yokoya, Hisanori Fukunaga","doi":"10.3769/radioisotopes.71.35","DOIUrl":null,"url":null,"abstract":"Fertility preservation in radiotherapy is of significance for the quality of life among post-treatment cancer survi-vors. In this study, using a mouse testicular tissue culture and a common X-ray irradiator, we analyzed the recovery process of spermatogenesis in spatially fractionated radiation fields, suggesting that spermatogonial stem cell migration may be involved in the recovery process. These tissue culture approaches are expected to provide a novel insight into the mechanisms of radiotherapy-related male infertility.","PeriodicalId":20809,"journal":{"name":"Radioisotopes","volume":"60 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2022-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Radioisotopes","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3769/radioisotopes.71.35","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Fertility preservation in radiotherapy is of significance for the quality of life among post-treatment cancer survi-vors. In this study, using a mouse testicular tissue culture and a common X-ray irradiator, we analyzed the recovery process of spermatogenesis in spatially fractionated radiation fields, suggesting that spermatogonial stem cell migration may be involved in the recovery process. These tissue culture approaches are expected to provide a novel insight into the mechanisms of radiotherapy-related male infertility.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
