Techniques used in orally disintegrating drug delivery system

Abstract

Formulation of a convenient dosage form for administration, by considering swallowing difficulty and poor patient compliance, leads to development of orally disintegrating tablets. This are also called as orodisperse, mouth dissolving, rapidly disintegrating, and fast melt system. This disintegrates in the mouth in seconds without chewing and the need of water which is advantageous mainly for pediatrics, geriatrics and patients having difficulty in swallowing tablets and capsules. Conventional preparation methods are spray drying, freeze drying, direct compression, Molding, and sublimation while new technologies have been developed for the production of orodispersible tablets. This review depicts conventional and recent technologies that are used to prepare orodispersible tablets in detail. Keywords: Orally disintegrating tablet; Superdisintegrant; Patented technologies; Orodispersible tablets