{"title":"CHOLESTASIS: MOLECULAR MECHANISM, PATHOGENESIS AND POSSIBLE MANAGEMENT","authors":"Basant Al-Botaty","doi":"10.21608/ajps.2018.46644","DOIUrl":null,"url":null,"abstract":"Understanding the molecular mechanism of bile formation and the different pathways and pathogenesis of drug induced cholestasis provide different possibilities for treatment. This review summarizes the role of transport proteins in hepatic drug clearance and toxicity, the involvement of inflammatory mediators in cholestasis and the role of nuclear receptors in bile acid metabolism. Understanding nuclear receptor function can help in the development of nuclear receptor ligands for treatment of cholestasis.","PeriodicalId":7603,"journal":{"name":"Al-Azhar Journal of Pharmaceutical Sciences","volume":"7 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2018-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Al-Azhar Journal of Pharmaceutical Sciences","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.21608/ajps.2018.46644","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Understanding the molecular mechanism of bile formation and the different pathways and pathogenesis of drug induced cholestasis provide different possibilities for treatment. This review summarizes the role of transport proteins in hepatic drug clearance and toxicity, the involvement of inflammatory mediators in cholestasis and the role of nuclear receptors in bile acid metabolism. Understanding nuclear receptor function can help in the development of nuclear receptor ligands for treatment of cholestasis.
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