Agar phantoms of biological tissue for fluorescence monitoring of photodynamic therapy

IF 0.9 4区 工程技术 Q3 Engineering Quantum Electronics Pub Date : 2022-01-01 DOI:10.1070/qel17967
A. Khilov, V.A. Shishkova, E. Sergeeva, D. Kurakina, M. Kirillin
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引用次数: 2

Abstract

An approach to fabricating agar phantoms mimicking spectral optical properties of biological tissues with fluorescent inclusions is proposed, which allows one to imitate the problem of optical visualisation of superficial biological tissues after the administration of a chlorin-based photosensitiser. The different arrangement of a fluorescent layer within a phantom makes it possible to simulate biological tissue in the cases of both topical application and intravenous injection of a photosensitiser. It is shown that absorption and scattering spectra of phantoms are in good agreement with the spectra of real biological tissues in the wavelength range of 500-800 nm. Changes in spectra of absorption and scattering coefficients of phantoms, as well as in their fluorescent properties induced by the addition of a fluorescent marker (chlorinbased photosensitiser) are demonstrated.
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用于光动力治疗荧光监测的生物组织琼脂幻影
提出了一种用荧光内含物制造模拟生物组织光谱光学特性的琼脂幻影的方法,这使得人们可以在使用氯基光敏剂后模拟表面生物组织的光学可视化问题。幻影内荧光层的不同排列使得在局部应用和静脉注射光敏剂的情况下模拟生物组织成为可能。结果表明,在500 ~ 800 nm的波长范围内,模拟物的吸收和散射光谱与真实生物组织的光谱具有较好的一致性。在光谱的吸收和散射系数的变化,以及在他们的荧光特性诱导荧光标记物(氯基光敏剂)的加入被证明。
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来源期刊
Quantum Electronics
Quantum Electronics 工程技术-工程:电子与电气
CiteScore
3.00
自引率
11.10%
发文量
95
审稿时长
3-6 weeks
期刊介绍: Quantum Electronics covers the following principal headings Letters Lasers Active Media Interaction of Laser Radiation with Matter Laser Plasma Nonlinear Optical Phenomena Nanotechnologies Quantum Electronic Devices Optical Processing of Information Fiber and Integrated Optics Laser Applications in Technology and Metrology, Biology and Medicine.
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