Musical Hallucinations Treated with Atypical Antipsychotics in a Geriatric Population – A Case Series

Adam Adam Schindzielorz, MD, D. Scott Murphy, MD, Suzanne Holroyd, MD
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Abstract

Musical hallucinations have been likened to the auditory equivalent of Charles Bonnet Syndrome, which involves complex visual hallucinations, most often in the context of visual impairment. Musical hallucination frequently take the form of hymns, carols, and show-tunes and are strongly associated with hearing loss, with some studies suggesting a prevalence of 2.5–3.6% in the hearing impaired. Musical hallucinations are typically treated with anticonvulsant and anticholinesterase medications, with some studies having evaluated the efficacy of sedative hypnotics, antipsychotics and antidepressants in various psychiatric and medical subpopulations suggesting a heterogeneous spectrum of causes for this disorder. We present two cases of musical hallucinations in both a 70-year-old African American female with past psychiatric history of major depressive disorder who developed hymnal auditory hallucinations during an acute medical and psychiatric admission and an 86-year-old Caucasian female, who complained of hearing gospel music with eventual onset of visual hallucinations after a fall at age 80. Our patients were successfully treated in both the inpatient and outpatient settings with atypical antipsychotics. The presented cases add to the paucity of literature regarding utilization of atypical antipsychotics for treatment of musical hallucinations and demonstrate efficacy to this effect. This study lends further validity to the use of psychopharmacologic agents for novel purposes that have yet to be fully explored.
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用非典型抗精神病药物治疗老年人群中的音乐幻觉-一个病例系列
音乐幻觉被比作听觉上的查尔斯·邦纳综合症,后者涉及复杂的视觉幻觉,最常出现在视觉障碍的情况下。音乐幻觉通常以赞美诗、颂歌和表演曲调的形式出现,与听力损失密切相关,一些研究表明,听力受损人群的患病率为2.5-3.6%。音乐幻觉通常用抗惊厥药和抗胆碱酯酶药物治疗,一些研究评估了镇静催眠药、抗精神病药和抗抑郁药在各种精神病学和医学亚群中的疗效,表明这种疾病的病因多种多样。我们报告了两例音乐幻觉的病例,分别是一位70岁的非裔美国女性,既往有重度抑郁症的精神病史,在急性医学和精神科入院期间出现了赞美性幻听;另一位86岁的白人女性,在80岁摔倒后抱怨听到福音音乐,最终出现了视觉幻觉。我们的病人都成功地治疗在住院和门诊设置与非典型抗精神病药物。所提出的案例增加了文献关于非典型抗精神病药物用于治疗音乐幻觉的缺乏,并证明了这种效果的有效性。这项研究进一步证明了精神药理学药物用于尚未充分探索的新目的的有效性。
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