{"title":"SYNTHESIS AND ANTIOXIDANT ACTIVITY OF SOME NEW SULFONAMIDE DERIVATIVES","authors":"Jovana Muskinja, Jelena S. Katanić Stanković, Z. Ratković","doi":"10.46793/iccbi21.351m","DOIUrl":null,"url":null,"abstract":"Sulfonamide derivatives are a very important class of compounds with pronounced biological activities and, for this reason, they have very useful pharmaceutical applications. They are the basis of several groups of drugs and are known as sulfa-drugs. From this point of view, the present study focuses on the synthesis of some novel structural hybrids incorporating two very important groups, sulfonamide, and pyrazoline. The new sulfonamide-based pyrazolines were synthesized in very good yields. The structures of the sulfonamide compounds were confirmed by IR and NMR methods. Synthesized compounds were tested for their antioxidant activities using two different methods, DPPH radical and ABTS radical cation scavenging assays. The results showed relatively good in vitro antioxidant activity.","PeriodicalId":9171,"journal":{"name":"Book of Proceedings: 1st International Conference on Chemo and BioInformatics,","volume":"50 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Book of Proceedings: 1st International Conference on Chemo and BioInformatics,","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.46793/iccbi21.351m","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

Sulfonamide derivatives are a very important class of compounds with pronounced biological activities and, for this reason, they have very useful pharmaceutical applications. They are the basis of several groups of drugs and are known as sulfa-drugs. From this point of view, the present study focuses on the synthesis of some novel structural hybrids incorporating two very important groups, sulfonamide, and pyrazoline. The new sulfonamide-based pyrazolines were synthesized in very good yields. The structures of the sulfonamide compounds were confirmed by IR and NMR methods. Synthesized compounds were tested for their antioxidant activities using two different methods, DPPH radical and ABTS radical cation scavenging assays. The results showed relatively good in vitro antioxidant activity.
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
磺胺类新衍生物的合成及抗氧化活性研究
磺胺衍生物是一类非常重要的化合物,具有显著的生物活性,因此具有非常有用的制药应用。它们是几组药物的基础,被称为磺胺类药物。从这个角度来看,本研究的重点是合成一些新的结构杂化化合物,其中包括两个非常重要的基团,磺胺和吡唑啉。合成了新的磺胺基吡唑啉,收率很高。通过红外光谱和核磁共振等方法对化合物的结构进行了确证。采用DPPH自由基清除法和ABTS自由基清除法测定合成化合物的抗氧化活性。结果表明,其体外抗氧化活性较好。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
自引率
0.00%
发文量
0
期刊最新文献
ELECTROPHILIC ORGANOSELENIUM COMPOUNDS AND SARS-COV-2: PRO-OXIDANT ACTIVITY AS A MORE PROMISING WAY TOWARDS THE DRUGGABILITY DIRECT SCAVENGING ACTIVITY OF 4,7-DIHYDROXYCOUMARIN DERIVATIVE TOWARDS SERIES OF CHLOROMETHYLPEROXY RADICALS PLATINUM(IV) COMPLEX AND ITS CORRESPONDING LIGAND SUPPRESS CELL MOTILITY AND PROMOTE EXPRESSION OF FRIZZLED-7 RECEPTOR IN COLORECTAL CANCER CELLS A META-HEURISTIC MULTI-OBJECTIVE APPROACH TO THE MODEL SELECTION OF CONVOLUTION NEURAL NETWORKS FOR URINARY BLADDER CANCER DIAGNOSIS NOVEL LIGANDS OF HUMAN CYP7 ENZYMES – POSSIBLE MODULATORS OF CHOLESTEROL BLOOD LEVEL: COMPUTER SIMULATION STUDIES
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1