[Vacuum-assisted glue obliteration of veins. Domestic technique of cyanoacrylate vein ablation].

Abstract

Objective: The aim of the study was to assess efficacy of a new method of cyanoacrylate obliteration of veins, analyzing immediate and remote results.

Patients and methods: The primary endpoints were the pain intensity during surgery (as assessed by the visual analogue scale), occlusion of the vein and severity of the venous disease according to the Venous Clinical Severity Score at various terms. The results were analyzed during the first 10 days after manipulation and then after 1, 3, 6, 12 and 24 months. This study included 37 patients who from October 2018 underwent cyanoacrylate obliteration of veins according to a new technique on a total of 44 lower extremities.

Results: We performed 41 manipulations on the great saphenous vein (93.2%) and 3 on the small saphenous vein (6.8%). The diameter of the target vein ranged from 0.3 to 1.0 cm (mean 0.63 cm), with the length varying from 10 to 50 cm (mean 30.9 cm). We used from 0.2 to 1.6 ml (mean 0.76 ml) of glue composition 'Sulfacrylate'. The average pain level was 1.6 (minimum - 1, maximum 4) according to the visual analogue scale. In the early postoperative period, there were no serious complications. The most frequent complication of the early period was cyanoacrylate phlebitis having appeared on POD 3-4. During the first 10 days, complete occlusion was observed in 100 % of cases. The occlusion rate at 1 month, 3 months, 6 months, 12 months and 24 months amounted to 93.2%, 86%, 90.2% and 84.6%, respectively, with no clinical relapses observed.

Conclusion: The technique of vacuum-assisted glue obliteration of veins using Russian-made glue composition 'Sulfacrylate' proved safe and effective. Further studies are warranted for accumulation of experience and follow up of remote results.