Caracterización de la nefritis tubulointersticial aguda en un centro de Cuba, 1988-2018

Abstract

Objectives: To know the frequency of presentation of acute tubulointerstitial nephritis (ATIN) in the last three decades, its forms of presentation, etiology, clinical manifestations and findings in the urinary sediment. Material and methods: A descriptive, retrospective cross-sectional study was carried out in Cuban patients who underwent kidney biopsy of own kidneys at the Nephrology Institute, Havana, Cuba, in the period 1988-2018. The information was processed in an automated way (SPSS 22.0). Analysis of frequency distribution, average and the homogeneity test were used. Results: Of 2472 biopsies performed, 77 (3.1%) were diagnosed as ATIN. The frequency of this diagnosis increased, from 1.1% in the period 1988-1998, to 3% in 1999-2008, up to 4.5% in the period 2009-2018 (p = 0.044). The main form of presentation was acute kidney injury (AKI) (83.1%), skin rash, eosinophilia and fever triad was present in 11.7% of patients and the most frequent cause was medication