ChemInform Abstract: Isolation of Lingzhifuran A and Lingzhilactones D—F from Ganoderma lucidum as Specific Smad3 Phosphorylation Inhibitors and Total Synthesis of Lingzhifuran A.

ChemInform Pub Date : 2016-12-06 DOI:10.1002/chin.201652385
Wei-Yi Ding, Jun Ai, Xin-Long Wang, Fayang G. Qiu, Qing Lv, Ping Fang, Fan-Fan Hou, Yong-Ming Yan, Yong-Xian Cheng
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Abstract

The four new phenolic meroterpenoids, lingzhifuran A (I) and lingzhilactones D—F (II—IV), show inhibitory activities against transforming growth factor-β1-induced Smad3 phosphorylation.

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摘要:灵芝呋喃A和灵芝内酯D-F作为Smad3特异性磷酸化抑制剂的分离及灵芝呋喃A的全合成。
四种新的酚类萜类化合物灵芝呋喃A (I)和灵芝内酯D-F (II-IV)对转化生长因子-β1诱导的Smad3磷酸化具有抑制作用。
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