{"title":"NBS promoted cascade reaction of β-anhydroicaritine and alcohols","authors":"Hanqi Cui, Xianheng Wang, Shuang Qian, Yuqi He, Changkuo Zhao","doi":"10.1080/17518253.2022.2148836","DOIUrl":null,"url":null,"abstract":"ABSTRACT An unusual NBS promoted cascade reaction of β-anhydroicaritine and alcohols was successfully developed to prepare chromane-3,4-dione 3 in a moderate yield. A mechanism was also put forward to explain this reaction. These chromane-3,4-dione derivatives showed a potent cytotoxicity against HepG2 and MCF-7 cell lines, which were expected to be a potential lead candidate for the treatment of liver cancer and breast cancer. GRAPHICAL ABSTRACT","PeriodicalId":12768,"journal":{"name":"Green Chemistry Letters and Reviews","volume":"14 1","pages":""},"PeriodicalIF":5.8000,"publicationDate":"2023-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Green Chemistry Letters and Reviews","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1080/17518253.2022.2148836","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
ABSTRACT An unusual NBS promoted cascade reaction of β-anhydroicaritine and alcohols was successfully developed to prepare chromane-3,4-dione 3 in a moderate yield. A mechanism was also put forward to explain this reaction. These chromane-3,4-dione derivatives showed a potent cytotoxicity against HepG2 and MCF-7 cell lines, which were expected to be a potential lead candidate for the treatment of liver cancer and breast cancer. GRAPHICAL ABSTRACT
期刊介绍：
Green Chemistry Letters and Reviews is an Open Access, peer-reviewed journal focused on rapid publication of innovative new syntheses and procedures that reduce or eliminate the use and generation of hazardous materials. Reviews of state-of-the-art green chemistry technologies are also included within the journal''s scope.
Green Chemistry Letters and Reviews is divided into three overlapping topic areas: research, education, and industrial implementation. The journal publishes both letters, which concisely communicate the most time-sensitive results, and reviews, which aid researchers in understanding the state of science on important green chemistry topics. Submissions are encouraged which apply the 12 principles of green chemistry to:
-Green Chemistry Education-
Synthetic Reaction Pathways-
Research and Process Analytical Techniques-
Separation and Purification Technologies-
Renewable Feedstocks-
Degradable Products
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