Synthesis and Antimicrobial Activity of some 1,4-Disubstituted 1,2,3-Triazoles

Abstract

We realized the highly selective synthesis of 1,4-disubstituted 1,2,3-triazoles starting from a terminal alkyne and arylazides, without the presence of metal catalyst, using the sequence hydroamination/1,3-dipolar cycloaddition reaction. The structure of synthesized products was determined by the usual spectroscopic methods (IR, 1 H NMR and 13 C NMR). The 1,2,3-triazoles obtained were tested for their antimicrobial properties. Most of them showed a significant antibacterial activity against Pseudomonas aeruginosa, Citrobacter freundii, Escherichia coli, Staphylococcus aureus, and a fungicidal activity against Aspergillus flavus and Aspergillus ochraceus.