{"title":"Reliability of fetal–infant mortality rates in perinatal periods of risk (PPOR) analysis","authors":"Vito L Di Bona","doi":"10.1515/em-2019-0026","DOIUrl":null,"url":null,"abstract":"Abstract The Fetal–Infant mortality rate (FIMR) is the basic surveillance statistic in perinatal periods of risk (PPOR) analyses. This paper presents a model for the FIMR as the ratio of two Poisson random variables. From this model, expressions for estimators of variance, standard error, and relative standard error are developed. The coverage properties of interval estimators for the FIMR are investigated in a simulation study for both small and large populations and FIMR rates. Results from these studies are applied to a PPOR analysis of NC vital records. Results suggest that the sample size guidance provided in the literature to ensure statistical reliability is overly conservative and interval construction methodology should be selected based on population size.","PeriodicalId":37999,"journal":{"name":"Epidemiologic Methods","volume":"125 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Epidemiologic Methods","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1515/em-2019-0026","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Mathematics","Score":null,"Total":0}
引用次数: 0
Abstract
Abstract The Fetal–Infant mortality rate (FIMR) is the basic surveillance statistic in perinatal periods of risk (PPOR) analyses. This paper presents a model for the FIMR as the ratio of two Poisson random variables. From this model, expressions for estimators of variance, standard error, and relative standard error are developed. The coverage properties of interval estimators for the FIMR are investigated in a simulation study for both small and large populations and FIMR rates. Results from these studies are applied to a PPOR analysis of NC vital records. Results suggest that the sample size guidance provided in the literature to ensure statistical reliability is overly conservative and interval construction methodology should be selected based on population size.
期刊介绍：
Epidemiologic Methods (EM) seeks contributions comparable to those of the leading epidemiologic journals, but also invites papers that may be more technical or of greater length than what has traditionally been allowed by journals in epidemiology. Applications and examples with real data to illustrate methodology are strongly encouraged but not required. Topics. genetic epidemiology, infectious disease, pharmaco-epidemiology, ecologic studies, environmental exposures, screening, surveillance, social networks, comparative effectiveness, statistical modeling, causal inference, measurement error, study design, meta-analysis
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