酚参与的不对称C-O键形成研究进展 Progress on Asymmetric C-O Bond Formation with Phenols

Abstract

手性芳基氧杂化合物在药物化学和临床治疗上有着及其重要的作用。酚与不同的反应底物发生不对称反应是获得此类化合物的重要途径。在手性催化剂的作用下，以酚为亲核试剂，与不同的反应底物可发生不对称取代、Oxa-Michael加成、开环、Wacker-Type环化、O-H插入等获得手性芳基氧杂化合物。近年来，酚参与不对称C-O键形成取得了较大的进展，本文将对该进展做重点介绍。 Chiral aryl oxa-compounds are extremely important in medicinal chemistry and clinical therapies. The asymmetric reactions of phenols with different substrates are important methodologies to synthesize such species. With phenols as nucleophilic reagents, the chiral catalysts-catalyzed asymmetric reactions, such as substitution, Oxa-Michael addition, ring-opening, Wacker-Type cy-clization, O-H insertion, can be developed by reacting with different substrates to obtain such compounds. Recently, the asymmetric C-O bond formation with phenols has made a great progress. This paper will focus on the progress of the asymmetric C-O bond formation with phenols.