{"title":"An in-plane microneedles used for sampling and glucose analysis","authors":"R. Liu, X.H. Wang, F. Tang, Y. Feng, Z. Zhou","doi":"10.1109/SENSOR.2005.1497372","DOIUrl":null,"url":null,"abstract":"We report here the design, fabrication and experiments of a hollow in-plane microneedle, with which a biosensor is integrated to extract interstitial fluid from skin for glucose measurement. The design of hollow in-plane microneedles leads to a simple fabrication process. Different from common methods for immobilizing enzyme, we use capillary force to immobilize enzyme on the surface of microelectrodes. The experimental results showed a good linearity for the characteristic curve of glucose concentration, when it varies from 0 to 500mg/dl with respect to current signal value. The sensitivity of 0.4238nA was obtained.","PeriodicalId":22359,"journal":{"name":"The 13th International Conference on Solid-State Sensors, Actuators and Microsystems, 2005. Digest of Technical Papers. TRANSDUCERS '05.","volume":"472 1","pages":"1517-1520 Vol. 2"},"PeriodicalIF":0.0000,"publicationDate":"2005-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"5","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"The 13th International Conference on Solid-State Sensors, Actuators and Microsystems, 2005. Digest of Technical Papers. TRANSDUCERS '05.","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1109/SENSOR.2005.1497372","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 5
Abstract
We report here the design, fabrication and experiments of a hollow in-plane microneedle, with which a biosensor is integrated to extract interstitial fluid from skin for glucose measurement. The design of hollow in-plane microneedles leads to a simple fabrication process. Different from common methods for immobilizing enzyme, we use capillary force to immobilize enzyme on the surface of microelectrodes. The experimental results showed a good linearity for the characteristic curve of glucose concentration, when it varies from 0 to 500mg/dl with respect to current signal value. The sensitivity of 0.4238nA was obtained.
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