Diagnostic Value of Adenosine Deaminase and Its Isoforms in Type II Diabetes Mellitus.

Q2 Biochemistry, Genetics and Molecular Biology Enzyme Research Pub Date : 2016-01-01 Epub Date: 2016-12-05 DOI:10.1155/2016/9526593

Bagher Larijani, Ramin Heshmat, Mina Ebrahimi-Rad, Shohreh Khatami, Shirin Valadbeigi, Reza Saghiri

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Abstract

Background and Aims. In the present study, we have investigated the activity of adenosine deaminase (ADA) as a diagnostic marker in type 2 (or II) diabetes mellitus (T2DM). Design and Methods. The deaminase activity of ADA1 and ADA2 was determined in serum from 33 patients with type 2 (or II) diabetes mellitus and 35 healthy controls. We also determined the proportion of glycated hemoglobin (HbA1c). Results. Our results showed significant differences between total serum ADA (tADA) and ADA2 activities in the diabetic groups with HbA1c < 8 (%) and HbA1c ≥ 8 (%) with respect to the values in healthy individuals (p < 0.001). ADA2 activity in patients with high HbA1c was found to be much higher than that in patients with low HbA1c (p = 0.0001). In addition, total ADA activity showed a significant correlation with HbA1c (r = 0.6, p < 0.0001). Conclusions. Total serum ADA activity, specially that due to ADA2, could be useful test for the diagnosis of type 2 (or II) diabetes mellitus.

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腺苷脱氨酶及其同工酶对 II 型糖尿病的诊断价值

背景和目的：在本研究中，我们探讨了作为 2 型（或 II 型）糖尿病（T2DM）诊断指标的腺苷脱氨酶（ADA）活性。设计与方法。我们测定了 33 名 2 型（或 II 型）糖尿病患者和 35 名健康对照者血清中 ADA1 和 ADA2 的脱氨酶活性。我们还测定了糖化血红蛋白（HbA1c）的比例。结果显示我们的结果显示，HbA1c < 8 (%) 和 HbA1c ≥ 8 (%) 的糖尿病组血清总 ADA (tADA) 和 ADA2 活性与健康人的值有明显差异（p < 0.001）。高 HbA1c 患者的 ADA2 活性远高于低 HbA1c 患者（p = 0.0001）。此外，总 ADA 活性与 HbA1c 呈显著相关性（r = 0.6，p < 0.0001）。结论血清总 ADA 活性，尤其是 ADA2 活性，可作为诊断 2 型（或 II 型）糖尿病的有用检测指标。

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来源期刊

Enzyme Research Biochemistry, Genetics and Molecular Biology-Biochemistry

CiteScore

4.60

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