{"title":"New mechanisms of neurite outgrowth and TrkA receptor activation/signaling","authors":"F. Colombo, J. Meldolesi","doi":"10.14800/RCI.542","DOIUrl":null,"url":null,"abstract":"The paper we recently published in PNAS, entitled “Neurite outgrowth induced by NGF or L1CAM via activation of the TrkA receptor is sustained also by the exocytosis of enlargeosomes” (Colombo et al., 2014), reported studies carried out in clones isolated from the PC12 line, frequently employed as a neuronal model. Two original and integrated findings were obtained, concerning the vesicle traffic and fusion processes necessary for neurite outgrowth, and the activation of TrkA, the tyrosine kinase receptor of NGF, by the adhesion protein L1CAM. Both these findings provide an explanation to results previously obtained in our and other laboratories.","PeriodicalId":20980,"journal":{"name":"Receptors and clinical investigation","volume":"37 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2015-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Receptors and clinical investigation","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.14800/RCI.542","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
The paper we recently published in PNAS, entitled “Neurite outgrowth induced by NGF or L1CAM via activation of the TrkA receptor is sustained also by the exocytosis of enlargeosomes” (Colombo et al., 2014), reported studies carried out in clones isolated from the PC12 line, frequently employed as a neuronal model. Two original and integrated findings were obtained, concerning the vesicle traffic and fusion processes necessary for neurite outgrowth, and the activation of TrkA, the tyrosine kinase receptor of NGF, by the adhesion protein L1CAM. Both these findings provide an explanation to results previously obtained in our and other laboratories.
我们最近在PNAS上发表的论文题为“NGF或L1CAM通过激活TrkA受体诱导的神经突生长也由增大体的胞外作用维持”(Colombo et al., 2014),报告了从PC12系分离的克隆中进行的研究,该克隆经常被用作神经元模型。我们获得了两个原始而完整的发现,关于神经突生长所需的囊泡运输和融合过程,以及粘附蛋白L1CAM对NGF酪氨酸激酶受体TrkA的激活。这两项发现都为我们和其他实验室先前获得的结果提供了解释。