{"title":"Rapid estimation of octanol–water partition coefficients using deoxycholate micelles in capillary electrophoresis","authors":"M. Adlard, G. Okafo, E. Meenan, P. Camilleri","doi":"10.1039/C39950002241","DOIUrl":null,"url":null,"abstract":"Deoxycholic acid micelles have been used successfully in capillary electrophoresis to estimate the octanol-water partition coefficient (log P) of a number of drugs; the methodology developed is fast and is suitable for the determination of this physico-chemical parameter for neutral, basic and weakly acidic molecules with a variety of structures.","PeriodicalId":17282,"journal":{"name":"Journal of The Chemical Society, Chemical Communications","volume":"1 1","pages":"2241-2243"},"PeriodicalIF":0.0000,"publicationDate":"1995-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"24","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of The Chemical Society, Chemical Communications","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1039/C39950002241","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 24
Abstract
Deoxycholic acid micelles have been used successfully in capillary electrophoresis to estimate the octanol-water partition coefficient (log P) of a number of drugs; the methodology developed is fast and is suitable for the determination of this physico-chemical parameter for neutral, basic and weakly acidic molecules with a variety of structures.
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