{"title":"RANDOMIZE: A Web Server for Data Randomization","authors":"A. Wani, Don Armstrong, J. Dahrendorff, M. Uddin","doi":"10.1101/2020.04.02.013656","DOIUrl":null,"url":null,"abstract":"Summary DNA methylation microarray data may suffer from batch effects due to improper handling of the samples during the plating process. RANDOMIZE is a web-based application designed to perform randomization of relevant metadata to evenly distribute samples across the factors typically responsible for batch effects in DNA methylation microarrays, such as row, chips and plates. Randomization helps to reduce the likelihood of bias and impact of difference among groups. Availability The tool is freely available online at https://coph-usf.shinyapps.io/RANDOMIZE/ and can be accessed using any web browser. Sample data and tutorial is also available with the tool. Contact ahwani@usf.edu","PeriodicalId":87222,"journal":{"name":"Archives of proteomics and bioinformatics","volume":"186 1","pages":"31 - 37"},"PeriodicalIF":0.0000,"publicationDate":"2020-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Archives of proteomics and bioinformatics","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1101/2020.04.02.013656","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 1
Abstract
Summary DNA methylation microarray data may suffer from batch effects due to improper handling of the samples during the plating process. RANDOMIZE is a web-based application designed to perform randomization of relevant metadata to evenly distribute samples across the factors typically responsible for batch effects in DNA methylation microarrays, such as row, chips and plates. Randomization helps to reduce the likelihood of bias and impact of difference among groups. Availability The tool is freely available online at https://coph-usf.shinyapps.io/RANDOMIZE/ and can be accessed using any web browser. Sample data and tutorial is also available with the tool. Contact ahwani@usf.edu
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