Formulation and evaluation of floating bioadhesive Doxofylline tablets

Abstract

In the present work, an attempt has been made to develop gastro retentive floating tablets of Doxofylline . HPMC K4M and carbopol were used as controlled release polymers . All the formulations were prepared by direct compression method on 12 station rotary tablet punching machine. The blend of all the formulations showed god flow properties such as angle of repose, bulk density, tapped density. The prepared tablets were shown good post compression parameters and they passed all the quality control evaluation parameters as per I.P limits. FH 5 was the best optimized floating formulation because it released drug completely in 12hrs.It was also observed that the increasing concentration of polymers had a retarding effect on the drug release from the polymer matrices.