КОГНИТИВНАЯ ОСЬ СТАРОСТИ: ВОСПАЛЕНИЕ - МИКРОБИОТА ТОНКОГО КИШЕЧНИКА

Q3 Medicine Zhurnal mikrobiologii, epidemiologii, i immunobiologii Pub Date : 2017-10-28 DOI:10.36233/0372-9311-2017-5-3-9

Ю. Ю. Филиппова, Александра Леонидовна Бурмистрова

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引用次数: 4

Abstract

Aim. Detect connection between cognitive dysfunction in senior people with systemic infection profile and small intestine microbiota structure. Materials and methods. 42 senior individuals were included into the study All the examined have been divided into 2 groups based on the results of psychic status: 20 individuals with moderate cognitive disorders - «active longevity» group and 22 individuals with pronounced cognitive deficiency - «mercy» group. Systemic inflammation status and structure and quantitative composition of microbiota of small intestine was determined in all the senior individuals using gas chromatography mass-spectrometry of microbial markers. Results. Interconnection between systemic level of cytokines and microbiota structure of small intestine in senior people with various cognitive status was determined. Significant correlations between levels of pro-inflammatory cytokine IL-6 in blood plasma and quantity of Propionibacterium jensenii, Moraxella spp., Bacillus cereus and Fusobacterium spp. in small intestine and the degree of cognitive failure were detected for the first time. Conclusion. The parameters obtained could be used as predictive biomarkers of cognitive dysfunction in senior people.

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老年认知轴:炎症是小肠的微生物。

的目标。检测全身性感染老年人认知功能障碍与小肠微生物群结构之间的联系。材料和方法。42名老年人被纳入研究，所有被调查者根据心理状态的结果被分为两组:20名中度认知障碍的人-“积极长寿”组和22名明显认知缺陷的人-“慈悲”组。采用气相色谱-质谱法测定所有老年人的全身炎症状态和小肠微生物群的结构和定量组成。结果。研究了不同认知状态老年人小肠系统细胞因子水平与肠道菌群结构的相互关系。首次检测到血浆促炎细胞因子IL-6水平与小肠延senpropionibacterium、Moraxella、cereus、Fusobacterium的数量与认知功能障碍程度有显著相关性。结论。所获得的参数可作为预测老年人认知功能障碍的生物标志物。

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