Synthesis and antibacterial activity of novel 3-substituted 1-(2-methyl-5-nitrophenyl)-5-oxopyrrolidine derivatives

Abstract

– The synthesis of novel azole derivatives has been accomplished during chemical transformations of the 1-(2-methyl-5-nitrophenyl)-5-oxopyrrolidine-3-carbohydrazide. The structure of the synthesized compounds was determined by NMR and IR spectroscopies. Most of the synthesized compounds were screened for their antibacterial activity against S. aureus, L. monocytogenes, E. coli, and P. aeruginosa bacteria strains. was used as a control for S. aureus, E. coli , P. aeruginosa , and L. monocytogenes .