ORIENT-31 as the Sakigake “Charging Samurai” Born of IMpower150 but Will MARIPOSA-2 IMPRESS in the “Meiji Modernization” of Post-3G EGFR TKI Progression?

IF 5.1 Q1 ONCOLOGY Lung Cancer: Targets and Therapy Pub Date : 2022-03-01 DOI:10.2147/LCTT.S355503
M. Nagasaka, S. Ou
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引用次数: 5

Abstract

Abstract Tyrosine kinase inhibitors (TKIs) have become the preferred first line therapy for those patients with non-small cell lung cancer (NSCLC) harboring epidermal growth factor receptor (EGFR) mutations. Given superior progression free survival (PFS) and overall survival (OS) when compared to earlier generations, third generation EGFR TKIs have become the first choice therapy in many parts of the world. Even though multiple strategies are in development to target both “on-target” and “off-target” resistance, the continuation of EGFR TKIs at the time of progression remains a controversial topic. This commentary focuses on both the ”classic” clinical trials of IMpower150 and IMPRESS and compares them to the recently reported ORIENT-31 and ongoing MARIPOSA-2 to discuss the future therapeutic strategies in the setting of progression post-third generation EGFR TKIs.
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作为IMpower150诞生的崎崎“冲锋武士”的东方-31,MARIPOSA-2是否会在3g后EGFR TKI进程的“明治近代化”中留下深刻印象?
酪氨酸激酶抑制剂(TKIs)已成为表皮生长因子受体(EGFR)突变的非小细胞肺癌(NSCLC)患者首选的一线治疗药物。由于与前几代相比,第三代EGFR TKIs的无进展生存期(PFS)和总生存期(OS)更高,因此已成为世界许多地区的首选治疗方法。尽管针对“靶标”和“脱靶”耐药的多种策略正在开发中,但EGFR tki在进展期间的持续治疗仍然是一个有争议的话题。本文将重点介绍IMpower150和IMPRESS的“经典”临床试验,并将其与最近报道的ORIENT-31和正在进行的MARIPOSA-2进行比较,以讨论第三代EGFR TKIs进展后的未来治疗策略。
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来源期刊
CiteScore
8.10
自引率
0.00%
发文量
10
审稿时长
16 weeks
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