Use of Biomarkers to Assess Environmental Exposures and Health Outcomes in Deployed Troops.

Q1 Medicine International Journal of Occupational and Environmental Medicine Pub Date : 2019-12-01 DOI:10.1097/JOM.0000000000001752

Timothy M Mallon, Pamela K Krahl, Kevin M Haines, D. Walker, T. Thatcher, C. Woeller, J. Thakar, P. Hopke, J. Gaydos, M. Smith, K. Uppal, Y. Go, Dean P. Jones, M. Utell

{"title":"Use of Biomarkers to Assess Environmental Exposures and Health Outcomes in Deployed Troops.","authors":"Timothy M Mallon, Pamela K Krahl, Kevin M Haines, D. Walker, T. Thatcher, C. Woeller, J. Thakar, P. Hopke, J. Gaydos, M. Smith, K. Uppal, Y. Go, Dean P. Jones, M. Utell","doi":"10.1097/JOM.0000000000001752","DOIUrl":null,"url":null,"abstract":"OBJECTIVE\nThis paper provides an overview of our Military Biomarkers Research Study (MBRS) designed to assess whether biomarkers can be used to retrospectively assess deployment exposures and health impacts related to deployment environmental exposures.\n\n\nMETHODS\nThe MBRS consists of four phases. Phase I was a feasibility study of stored sera. Phase II looks at associations between exposures and biomarkers. Phase III examines relationships of biomarkers and health outcomes, and Phase IV investigates in vitro biomarker changes associated with exposures to chemicals of interest. This paper briefly summarizes work already published and introduces the new reports contained in this supplement.\n\n\nRESULTS\nNovel biomarkers were identified. These were associated with deployment exposures.\n\n\nCONCLUSIONS\nSignificant associations were noted between deployment exposures, microRNA biomarkers and metabolomic biomarkers, and deployment health outcomes.","PeriodicalId":46545,"journal":{"name":"International Journal of Occupational and Environmental Medicine","volume":"81 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"5","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Occupational and Environmental Medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1097/JOM.0000000000001752","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"Medicine","Score":null,"Total":0}

引用次数: 5

Abstract

OBJECTIVE This paper provides an overview of our Military Biomarkers Research Study (MBRS) designed to assess whether biomarkers can be used to retrospectively assess deployment exposures and health impacts related to deployment environmental exposures. METHODS The MBRS consists of four phases. Phase I was a feasibility study of stored sera. Phase II looks at associations between exposures and biomarkers. Phase III examines relationships of biomarkers and health outcomes, and Phase IV investigates in vitro biomarker changes associated with exposures to chemicals of interest. This paper briefly summarizes work already published and introduces the new reports contained in this supplement. RESULTS Novel biomarkers were identified. These were associated with deployment exposures. CONCLUSIONS Significant associations were noted between deployment exposures, microRNA biomarkers and metabolomic biomarkers, and deployment health outcomes.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

使用生物标志物评估部署部队的环境暴露和健康结果。

目的概述了我们的军事生物标志物研究(MBRS)，该研究旨在评估生物标志物是否可用于回顾性评估部署暴露和与部署环境暴露相关的健康影响。方法MBRS分为4个阶段。第一阶段是储存血清的可行性研究。第二阶段研究暴露与生物标志物之间的关系。第三阶段研究生物标志物与健康结果的关系，第四阶段研究与暴露于感兴趣的化学物质相关的体外生物标志物变化。本文简要总结了已发表的工作，并介绍了本增刊所载的新报告。结果鉴定出新的生物标志物。这些都与部署公开相关。结论部署暴露、microRNA生物标志物和代谢组学生物标志物与部署健康结果之间存在显著相关性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊