Feasibility study of using montmorillonite for stability enhancement of l-ascorbic acid

Yuan-Haun Lee , Bor-Yann Chen , Kun-Yu Lin , King-Fu Lin , Feng-Huei Lin
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引用次数: 5

Abstract

This study tended to construct new l-ascorbic acid (LAA) composites in low toxicity and high stability for feasible application. LAA is chemically very unstable, since it is easily oxidized into biologically inactive compounds naturally. Our finding showed that introduction of montmorillonite (MMT) could significantly attenuate its toxicity and to sustain the stability of LAA with economic feasibility for practical uses. In addition, as phosphoric acid was biologically compatible, it was used for the pretreatment of MMT to obtain a promising stabilization of LAA. Toxicity assessment also showed that MMT treated with low-concentration acids should be considered as biologically safe according to our assessment. Thus, using acid treated MMT to stabilize LAA in a long-term might be technically feasible for further uses.

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蒙脱土增强l-抗坏血酸稳定性的可行性研究
本研究旨在构建低毒性、高稳定性的新型l-抗坏血酸(LAA)复合材料。LAA在化学上非常不稳定,因为它很容易自然地被氧化成无生物活性的化合物。研究结果表明,蒙脱土的引入可以显著降低其毒性,并保持LAA的稳定性,具有实际应用的经济可行性。此外,由于磷酸具有生物相容性,因此将其用于MMT的预处理,以获得很好的LAA稳定化效果。毒性评价还表明,经低浓度酸处理的MMT在生物学上是安全的。因此,使用酸处理的MMT来长期稳定LAA在技术上可能是可行的。
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