The Association between mrna Expression Levels of Ephx1 and Prognosis of Acute Myeloid Leukemia

Journal of Integrative Oncology Pub Date : 2015-12-13 DOI:10.4172/2329-6771.1000154

Chong-mei Huang, Hui Cheng, Xiaoqian Xu, Xianmin Song, Li Chen, Jianmin Yang

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引用次数: 6

Abstract

The human epoxide hydrolase 1 (EPHX1) is a metabolism gene, which is responsible for the first phase of the xenobiotic metabolism. The product, microsomal epoxide hydrolase (mHE), plays an important role in the detoxification of carcinogenic polycyclic aromatic hydrocarbons. Many reports also have studied the correlation between EPHX1 gene polymorphisms and development and generation of cancers. However, few of studies on EPHX1 participating in chemotherapeutics metabolism were reported. The purpose of the present study was to evaluate the prognostic significance of the EPHX1gene expression in acute myeloid leukemia (AML). Using real timeâquantitative polymerase chain reaction (RTâqPCR), mRNA expression levels of EPHX1gene was measured in bone marrow samples of newly diagnosed AML patients (n=46) and control group (n=12) without tumors. The levels expression of EPHX1 had a significant association with the treatment response and prognosis of AML patients. Additionally, the EPHX1 expression levels can aid for an improved understanding of the multidrug resistant mechanism in AML.

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Ephx1 mrna表达水平与急性髓系白血病预后的关系

人环氧化物水解酶1 (EPHX1)是一个代谢基因，它负责外源代谢的第一阶段。产物微粒体环氧化物水解酶(mHE)在致癌物多环芳烃的解毒中起重要作用。许多报道也研究了EPHX1基因多态性与癌症发展和发生的相关性。然而，关于EPHX1参与化疗药物代谢的研究报道较少。本研究的目的是评估ephx1基因表达在急性髓性白血病(AML)中的预后意义。采用实时定量聚合酶链反应(rt qPCR)技术，检测新诊断AML患者(n=46)和无肿瘤对照组(n=12)骨髓样品中ephx1基因mRNA表达水平。EPHX1的表达水平与AML患者的治疗反应和预后有显著相关性。此外，EPHX1的表达水平可以帮助我们更好地了解AML的多药耐药机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Journal of Integrative Oncology

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