Experimental evidences of methanolic extraction of Cressa cretica Linn. on alloxan induced hyperglycemic Wistar rats

Abstract

In the present study, the physico-metabolic parameters measured were: serum insulin, serum lipid profile, serum biomarker enzymes and anti-oxidant enzymes, total cholesterol, HDL cholesterol, triglycerides, LDL cholesterol, VLDL cholesterol, total proteins, alanine transaminase (ALT), aspartate transaminase (AST), creatinine, insulin assay (RIA), for in vivo anti-oxidant activity of MECC was measured in liver tissue homogenate (LTH) by malondialdehyde (MDA), glutathione (GSH), superoxide dismutase (SOD) enzymes and histopathological examination of pancreas were also observed. Previously, the methonolic extract of Cressa cretica Linn. effect on alloxan induced hyperglycemic Wistar rats was proved by taking the parameters like body weight, blood glucose, glycogen content in liver and muscle. Oral administration of MECC (200 mg/kg, 400 mg/kg) for 28 days exhibited a significant reduction in blood glucose, serum ALT, AST, CR, lipid profile and hepatic MDA levels. The improvement of hepatic enzymes such as GSH, serum TP, HDL, insulin levels were also observed. The results of this work also suggest that MECC may possess anti-hyperglycemic and anti-oxidant property.