{"title":"Effects of inhibitors and activators on the activity of two diaphorases from Drosophila virilis","authors":"T.G. Georgieva, B.C. Dunkov, K.H. Ralchev","doi":"10.1016/0020-1790(91)90044-F","DOIUrl":null,"url":null,"abstract":"<div><p>The effect of some inhibitors and activators of mammalian DT-diaphorase on diaphorase-1 (DIA-1) and diaphorase-2′ (DIA-2′) purified from <em>Drosophila virilis</em> was studied. The inhibitors and activators changed the activity of these diaphorases in a different way, revealing a similarity between mammalian DT-diaphorase and <em>D. virilis</em> DIA-1 on the one hand and on the other between the <em>D. virilis</em> DIA-1 and the diaphorase purified from <em>Bombyx mori</em> eggs. These effects also confirm the independent genetic control of DIA-1 and DIA-2′ in <em>D. virilis</em> and make possible the differentiation of these diaphorase activities in crude enzyme extracts.</p></div>","PeriodicalId":13955,"journal":{"name":"Insect Biochemistry","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0020-1790(91)90044-F","citationCount":"3","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Insect Biochemistry","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/002017909190044F","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 3
Abstract
The effect of some inhibitors and activators of mammalian DT-diaphorase on diaphorase-1 (DIA-1) and diaphorase-2′ (DIA-2′) purified from Drosophila virilis was studied. The inhibitors and activators changed the activity of these diaphorases in a different way, revealing a similarity between mammalian DT-diaphorase and D. virilis DIA-1 on the one hand and on the other between the D. virilis DIA-1 and the diaphorase purified from Bombyx mori eggs. These effects also confirm the independent genetic control of DIA-1 and DIA-2′ in D. virilis and make possible the differentiation of these diaphorase activities in crude enzyme extracts.
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