METHODOLOGY FOR THE APPLICATION OF THE SUPRAMOLECULAR COMPLEX OF IVERMECTIN "ANIVERM-2.0%" AGAINST PARASITOSIS OF HERD HORSES

THEORY AND PRACTICE OF PARASITIC DISEASE CONTROL Pub Date : 2023-04-17 DOI:10.31016/978-5-6048555-6-0.2023.24.325-330

M. Musaev, V. V. Zashchepkina

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Abstract

Deworming untamed herd horses is a difficult task. It is more convenient to use drugs by free feeding, individually or in groups in a mixture with concentrated feed. In this regard, we have developed a new dosage form for the treatment and prevention of parasitosis in herd horses by free feeding in a mixture with concentrated feed based on the substance ivermectin, which has a high antiparasitic activity and a wide spectrum of action. To obtain an antiparasitic supramolecular complex based on the substance ivermectin, an innovative mechanochemical technology was used using two water-soluble polymers of low molecular weight polyvinylpyrrollydon-17 and natural arabinogalactan. The aim of the work is to develop a methodology for the use of the supramolecular complex ivermectin "Aniverm-2.0%" against parasitosis of herd horses. The drug "Aniverm-2.0%" is a supramolecular complex of ivermectin, a water-soluble solid powder of a light beige color, tasteless, with an easily perceptible coniferous odor. The methodology provides a brief description of the drug, its mechanism of action, pharmaco-toxicological properties, the procedure for use, the timing of slaughtering animals and personal safety measures. According to the degree of impact on the body of warm-blooded animals, the drug "Aniverm-2.0%" belongs to low-toxic substances.

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伊维菌素“anverm -2.0%”超分子复合物防治马群寄生虫病的方法学研究

给未驯服的牧马驱虫是一项艰巨的任务。自由饲喂、单用或成组与浓缩饲料混合使用更方便。在这方面，我们开发了一种新的剂型，通过以伊维菌素为基础的物质与浓缩饲料混合自由喂养来治疗和预防牧马寄生虫病，该物质具有高的抗寄生虫活性和广泛的作用谱。采用创新的机械化学技术，以低分子量聚乙烯吡啶酮-17和天然阿拉伯半乳聚糖两种水溶性聚合物为原料，制备了以伊维菌素为基础的抗寄生虫超分子复合物。这项工作的目的是开发一种使用超分子复合物伊维菌素“Aniverm-2.0%”来治疗马群寄生虫病的方法。药物“Aniverm-2.0%”是一种伊维菌素的超分子复合物，是一种浅米色的水溶性固体粉末，无味，有一种容易察觉的针叶气味。该方法对药物、其作用机制、药理学特性、使用程序、屠宰动物的时间和个人安全措施进行了简要描述。根据对温血动物机体的影响程度，药物“anverm -2.0%”属于低毒物质。

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THEORY AND PRACTICE OF PARASITIC DISEASE CONTROL

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