A One-pot Multi-component Synthesis of Dihydropyrimidinone/Thione and Dihydropyridine Derivatives via Biginelli and Hantzsch Condensations using t-BuOK as a Catalyst Under Solvent-free Conditions

A. Debache, Louisa Chouguiat, R. Boulcina, B. Carboni
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引用次数: 29

Abstract

The synthesis of various substituted Biginelli 3,4-dihydropyrimidinone/thione and Hantzsch 1,4- dihydropyridine derivatives has been achieved using a modified procedure in the presence of potassium ter-butoxide (t- BuOK) as a catalyst under solvent-free conditions, in good to excellent yields.
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无溶剂条件下,t-BuOK催化Biginelli缩合和Hantzsch缩合一锅多组分合成二氢嘧啶/硫酮和二氢吡啶衍生物
在无溶剂条件下,以叔丁醇钾(t- BuOK)为催化剂,采用改进的方法合成了各种取代的Biginelli 3,4-二氢嘧啶酮/硫酮和Hantzsch 1,4-二氢吡啶衍生物,收率很高。
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