Lactic acidosis.

Abstract

Certain HIV drugs in the nucleoside reverse transcriptase inhibitor (NRTI) class sometimes have negative side effects [2] that may lead to liver and other problems. One such side effect is damage to the mitochondria inside your cells, or mitochondrial toxicity. When mitochondria are damaged, lactic acid production is increased. This can cause levels of lactic acid in your blood to rise. If the levels of lactic acid become too high, a rare, but serious condition called lactic acidosis can occur.