J. Neu, Ayaka S. Hatano, E. Stone, Golo Storch, Jacob A. Spies, Scott J. Miller, C. Schmuttenmaer
{"title":"Identifying Peptide Structures with THz Spectroscopy","authors":"J. Neu, Ayaka S. Hatano, E. Stone, Golo Storch, Jacob A. Spies, Scott J. Miller, C. Schmuttenmaer","doi":"10.1109/IRMMW-THZ.2018.8510212","DOIUrl":null,"url":null,"abstract":"Short peptides composed of only a few amino acid residues are of great interest due to their biological activity and have also been shown to exhibit catalytic activity. Identifying their dynamic $3\\mathbf{D}$ structure is quintessential for studying structure - activity relations. We present temperature-dependent THz spectroscopy of tetrameric peptide catalysts. These THz spectra, supported by DFT calculations, allow us to distinguish structural features of different peptides.","PeriodicalId":6653,"journal":{"name":"2018 43rd International Conference on Infrared, Millimeter, and Terahertz Waves (IRMMW-THz)","volume":"84 1","pages":"1-2"},"PeriodicalIF":0.0000,"publicationDate":"2018-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"2018 43rd International Conference on Infrared, Millimeter, and Terahertz Waves (IRMMW-THz)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1109/IRMMW-THZ.2018.8510212","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 1
Abstract
Short peptides composed of only a few amino acid residues are of great interest due to their biological activity and have also been shown to exhibit catalytic activity. Identifying their dynamic $3\mathbf{D}$ structure is quintessential for studying structure - activity relations. We present temperature-dependent THz spectroscopy of tetrameric peptide catalysts. These THz spectra, supported by DFT calculations, allow us to distinguish structural features of different peptides.
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