Investigation of the protective and therapeutic effects of β-aminoisobutyric acid (BAIBA) and Thymoquinone in the diabetic nephropathy

Latin American and Caribbean Bulletin of Medicinal and Aromatic Plants Pub Date : 2021-05-30 DOI:10.37360/BLACPMA.21.20.3.22

I. Aktas, F. Gur

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引用次数: 7

Abstract

In this study, against streptozotocin (STZ) induced diapetic nephropathy (DN); it is aimed to investigate the use of thymoquinone (TQ) and β-aminoisobutyric acid (BAIBA) and to compare the effects of these agents. With randomselection of 35 male rats, five groups (seven rats in each group) were constituted as follows: Control, STZ, STZ + TQ, STZ + BAIBA, STZ + TQ + BAIBA. In the STZ group; body weight, glutathione (GSH) and insulin levels decreased, relative kidney weight, malondialdehyde (MDA), glucose, blood urea nitrogen (BUN) and creatinine (Cr) levels were increased. Also, in kidney tissue; histopathological changes (such as thickening of the capsular, glomerular and tubular basement membranes, increased mesangial matrix amount, increased cytoplasmic vacuolization in some of the tubular epithelial cells, increased tumor necrosis factor-alpha (TNF-α) expression, and inflammatory cell infiltrations in interstitial tissue) were detected. It was observed that these changes occurring after diabetes mellitus (DM) reversed significantly in TQ, BAIBA and TQ + BAIBA groups.

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β-氨基异丁酸(BAIBA)和百里醌对糖尿病肾病的保护和治疗作用的研究

在本研究中，抗链脲佐菌素(STZ)诱导的糖尿病肾病(DN);目的是研究百里醌(TQ)和β-氨基异丁酸(BAIBA)的使用情况，并比较它们的效果。随机选取35只雄性大鼠，分为5组(每组7只):对照组、STZ、STZ + TQ、STZ +白霸、STZ + TQ +白霸。在STZ组;体重、谷胱甘肽(GSH)和胰岛素水平降低，相对肾重、丙二醛(MDA)、葡萄糖、血尿素氮(BUN)和肌酐(Cr)水平升高。同样，在肾组织中;组织病理学改变(如囊膜、肾小球和肾小管基底膜增厚，系膜基质数量增加，部分肾小管上皮细胞胞浆空泡化增加，肿瘤坏死因子α (TNF-α)表达增加，间质组织炎症细胞浸润)。观察发现，TQ组、百巴组和TQ +百巴组在糖尿病(DM)后发生的这些变化均显著逆转。

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Latin American and Caribbean Bulletin of Medicinal and Aromatic Plants

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