Effect Of Alpha-Tocopherol On Spermatozoa Death Of Apoptosis and Necrosis in Rats (Rattus Norvegicus) Exposed 2,3,7,8- Tetrachlorodibenzo-P-Dioxin

Journal of Stem Cell Research and Tissue Engineering Pub Date : 2021-01-01 DOI:10.20473/jscrte.v5i1.29381

Valderama Gomang

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Abstract

The aims of this research was to investigate effect of alpha-tocopherol on spermatozoa death in form of apoptosis and necrosis in rats (Rattus norvegicus) exposed 2,3,7,8- tetrachlorodibenzo-p-dioxin. Male rats were administered TCDD and alpha-tocopherol in experimental groups. Five experimental groups of a combination of TCDD and alpha- tocopherol were designed as follows; 0.5 ml of corn oil (control negative group, K-), 700 ng/kg/d of TCDD and 0.5 ml of corn oil (treatment control), 700 ng/kg/d of TCDD and 77 ng/kg/d of alpha-tocopherol (Group P1), 700 ng/kg/d of TCDD and 140 mg/kg/d of alpha-tocopherol (Group P2), 700 ng/kg/d of TCDD and 259 mg/kg/d of alpha- tocopherol (Group P3) respectively. Alpha-tocopherol and TCDD were given by oral gavage for 20 days. The result indicated that TCDD increased spermatozoa death in form of apoptosis and also necrosis. Alpha-tocopherol at 259 mg/kg/d most effective to decreased spermatozoa death number. The conclusion indicated that alpha-tocopherol at 259 mg/kg/d effective to decreased the spermatozoa death in form of apoptosis and necrosis in rats (Rattus norvegicus) exposed 2,3,7,8-tetrachlorodibenzo-p-dioxin.

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α -生育酚对2,3,7,8-四氯二苯并-对二恶英暴露大鼠精子凋亡和坏死的影响

本研究旨在探讨α -生育酚对暴露于2,3,7,8-四氯二苯并-对二恶英大鼠(Rattus norvegicus)精子凋亡和坏死的影响。实验组雄性大鼠给予TCDD和α -生育酚。TCDD与α -生育酚联合用药5个试验组设计如下:玉米油0.5 ml(对照阴性组，K-)， TCDD 700 ng/kg/d和0.5 ml玉米油(处理对照)，TCDD 700 ng/kg/d和α -生育酚77 ng/kg/d (P1组)，TCDD 700 ng/kg/d和α -生育酚140 mg/kg/d (P2组)，TCDD 700 ng/kg/d和α -生育酚259 mg/kg/d (P3组)。α -生育酚和TCDD灌胃治疗20 d。结果表明，TCDD使精子以凋亡和坏死的形式死亡。α -生育酚浓度为259 mg/kg/d时对降低精子死亡数量最有效。结果表明，259 mg/kg/d的α -生育酚能有效降低2,3,7,8-四氯二苯并-对二恶英暴露大鼠的精子凋亡和坏死。

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Journal of Stem Cell Research and Tissue Engineering

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