One-Pot Synthesis of Substituted Coumarins Catalyzed by Silica Gel Supported Sulfuric Acid Under Solvent-Free Conditions

M. ReddyBenjaram, Thirupathi Boningari, K. PatilMeghshyam
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引用次数: 29

Abstract

A remarkable acceleration in the synthesis of substituted coumarins via Pechmann reaction catalyzed by silica gel supported sulfuric acid (H2SO4/silica gel) at 120 °C in high yields under solvent-free reaction condition with short re- action times is described. This methodology offers momentous improvements over various options for the synthesis of coumarins with regard to yield of products, simplicity in operation and green aspects by avoiding toxic catalysts and sol- vents.
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无溶剂条件下硅胶负载硫酸催化一锅法合成取代香豆素
在120℃无溶剂条件下,用硅胶负载硫酸(H2SO4/硅胶)催化Pechmann反应合成取代香豆素,收率高,反应时间短。该方法在香豆素合成的收率、操作简单性和避免有毒催化剂和溶剂的绿色方面都有重大的改进。
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