Evaluation of some hematological parameters and C-reactive protein among men and women with osteoarthritis

Abstract

Osteoarthritis (OA) is a biomechanical phenomenon where the joints are susceptible to mechanical stress, resulting in reduced articular cartilage and changes in other knee tissue. It is characterized by joint pain, stiffness, loss of motion resulting in functional limitation, and disability. There are many risk factors lead to OA such as gender, aging, obesity, and joint injury. Blood samples obtained from 40 patients (23 females and 17 males) and 20 controls (10 females and 10 males), age years ranged (56.88 ± 2.57; 60.95 ± 1.57)in patients men and in women. (47.50 ± 1.50; 49.60 ± 1.30)in control men and women .The samples were collected from January to April 2019 in the Medical City, Baghdad. The study focuses on some hematological and C-reactive protein tests in patients with OA and controls. Erythrocyte sedimentation Rate(ESR) in patients men and women shows significant increase (P<0.01) in comparison with control ESR also increased significantly (p<0.05)in patient women (40.13 ± 6.43) in comparison with patients men (25.88 ± 6.38).Packed cell volume (PCV %) and hemoglobin (Hb) shows nonsignificant differences (P>0.05) in patients men and women in comparison with control while PCV (37.04 ± 0.98) and Hb (12.29 ± 0.32) in patients women decreased significantly (P<0.05) in comparison with patient men PCV (45.82 ± 1.06)and Hb (14.88 ± 0.38). In patients men (7.80 ± 2.62) and women (14.16 ± 2.15) .The C-reactive protein (CRP) increased significantly (P<0.01)respectively when compared with control men (2.90 ± 0.45) and control women (3.12 ± 0.34). CRP in patients women (14.16 ± 2.15) shows significant increase (P<0.01) in comparison with patients men (7.80 ± 2.62).