{"title":"Isolation, Characterization and Analgesic Activity of Natural Allantoin from Portulaca oleracea Seed","authors":"Hengli Wang, C. Wang","doi":"10.4172/2329-6798.1000249","DOIUrl":null,"url":null,"abstract":"The title compound, allantoin was first isolated from the acetyl acetate fraction of Portulaca oleracea seed and characterized by 1H-NMR and 13C-NMR. The analgesic activity of allantoin was assessed in acetic acid-induced writhing test in mice with i.p. injection. The results of the research indicated that the analgesic activity of allantoin was similiar to that of aspirine. After administrated of allantoin regularly and repeatedly, the mice did not reveal addiction phenomenon. Allantoin could be further studied as a promising analgesic drug.","PeriodicalId":18605,"journal":{"name":"Modern Chemistry & Applications","volume":"47 1","pages":"1-3"},"PeriodicalIF":0.0000,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"6","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Modern Chemistry & Applications","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4172/2329-6798.1000249","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 6
Abstract
The title compound, allantoin was first isolated from the acetyl acetate fraction of Portulaca oleracea seed and characterized by 1H-NMR and 13C-NMR. The analgesic activity of allantoin was assessed in acetic acid-induced writhing test in mice with i.p. injection. The results of the research indicated that the analgesic activity of allantoin was similiar to that of aspirine. After administrated of allantoin regularly and repeatedly, the mice did not reveal addiction phenomenon. Allantoin could be further studied as a promising analgesic drug.
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