微波辅助以烯胺酮(酯)为砌块高效构筑含氮杂环化合物的研究进展 Advances in the Study of Microwave Irradiation Efficient Construction of Heterocyclic Compounds with Enaminone or Enamino Ester as Building Blocks

白海瑞, 王晓晶, 付黄梅, 王平, 黄超
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Abstract

诸多天然产物分子和合成化合物都含有氮杂环结构并具有潜在的药物活性。采用微波照射的方法高效构筑含氮的五元、六元、多元环化合物是绿色合成杂环类化合物的重要途径,也是当今有机合成化学领域研究的热点。本文以微波合成为主旨,综述了烯胺酮(酯)为合成砌块高效构筑含氮杂环化合物的研究进展。 Nitrogen-containing heterocyclic structures often are ubiquitous scaffolds in many natural products and usually exhibit diverse biological activities. Microwave irradiation synthesis has been recognized as an important method for the environmentally-friendly preparations of novel heter-ocyclic compounds, and attracted the interest of some scientific researchers. In this review, the recent progress of microwave irradiation construction of heterocyclic compounds with enaminone or enamino ester is summarized, and a full vision of its development is made.
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微波辅助以烯胺酮(酯)为砌块高效构筑含氮杂环化合物的研究进展 Advances in the Study of Microwave Irradiation Efficient Construction of Heterocyclic Compounds with Enaminone or Enamino Ester as Building Blocks
诸多天然产物分子和合成化合物都含有氮杂环结构并具有潜在的药物活性。采用微波照射的方法高效构筑含氮的五元、六元、多元环化合物是绿色合成杂环类化合物的重要途径,也是当今有机合成化学领域研究的热点。本文以微波合成为主旨,综述了烯胺酮(酯)为合成砌块高效构筑含氮杂环化合物的研究进展。 Nitrogen-containing heterocyclic structures often are ubiquitous scaffolds in many natural products and usually exhibit diverse biological activities. Microwave irradiation synthesis has been recognized as an important method for the environmentally-friendly preparations of novel heter-ocyclic compounds, and attracted the interest of some scientific researchers. In this review, the recent progress of microwave irradiation construction of heterocyclic compounds with enaminone or enamino ester is summarized, and a full vision of its development is made.
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