A Third Musketeer on the ER: MOSPD2 is a Novel VAP-related Receptor for FFAT Motifs

Contact Pub Date : 2018-11-15 DOI:10.1177/2515256418809730
Thomas Di Mattia, C. Tomasetto, F. Alpy
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Abstract

Interorganelle membrane contact sites are subcellular structures that favor exchange and communication inside the cell. Such microdomains are built by molecular bridges that create a physical connection between two distinct organelles. The field of contact sites is now flourishing with discoveries of new tethering molecules. In that context, we identified by an unbiased proteomic approach a novel scaffold protein named MOtile SPerm Domain-containing protein 2 (MOSPD2). MOSPD2 is an endoplasmic reticulum (ER)-resident protein that is able to interact with several organelle-bound proteins that possess a small motif, named FFAT (two phenylalanines in an acidic tract). Consequently, we showed that MOSPD2 and its protein partners build contacts between the ER and endosomes, mitochondria, or Golgi. These findings highlight a new way for docking organelles on the ER.
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ER的第三个火枪手:MOSPD2是FFAT基序的一种新的vap相关受体
细胞器间膜接触位点是有利于细胞内交换和通讯的亚细胞结构。这种微域是由分子桥构建的,它在两个不同的细胞器之间建立了物理连接。随着新的系绳分子的发现,接触点领域正在蓬勃发展。在这种情况下,我们通过一种无偏倚的蛋白质组学方法鉴定了一种名为运动精子结构域蛋白2 (MOSPD2)的新型支架蛋白。MOSPD2是一种内质网(ER)居住蛋白,能够与几种具有小基序的细胞器结合蛋白相互作用,称为FFAT(酸性通道中的两个苯丙氨酸)。因此,我们发现MOSPD2及其蛋白伙伴在内质网和核内体、线粒体或高尔基体之间建立了联系。这些发现强调了在ER上对接细胞器的新方法。
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