Lessons from Immune Escape Mechanisms of Embryo Development in Uterus

Abstract

The development of semi-allogenic embryo in uterus during pregnancy is an immunological paradox, the im - mune tolerance in the fetomaternal interface is naturally established to prevent the embryo rejection. Solid tumors exist as a “new life” develop years, employ local or distant body nutrients to adapt, grow and metastasize to different organs of host. The development of embryo and tumor shares numerous similarities across the immune landscape and microenvironmental factors. Lessons from embryo development can increase our understanding on tumorigenesis and its components that could potentially transform anticancer therapeutic interventions